Shorter patient survival was generally associated with up-regulation of genes involved in mitosis and cell growth, and down-regulation of genes involved in cellular differentiation. The research also showed that gene expression patterns of individual tumors varied considerably, and could exceed the variation observed between different cancer types. Firstly, many genes are differentially expressed in cancers, and a large proportion of these genes have an impact on overall patient survival. The research reports several important findings related to cancer biology and treatment. The Pathology Atlas also contains 5 million pathology-based images generated by the Human Protein Atlas consortium. A national supercomputer center were used to analyze more than 2.5 petabytes of underlying publicly available data from the Cancer Genome Atlas (TCGA) to generate more than 900,000 survival plots describing the consequence of RNA and protein levels on clinical survival. In addition, we show a new concept to present patient survival data, called Interactive Survival Scatter plots, and in the atlas, we present more than 400,000 plots. The Human Pathology Atlas is based on a systems-based analysis of the transcriptome of 17 main cancer types using data from 8000 patients. The Human Protein Atlas consortium is mainly funded by the Knut and Alice Wallenberg Foundation. The Human Protein Atlas program has already contributed to several thousands of publications in the field of human biology and disease and it is selected by the organization ELIXIR (as a European core resource due to its fundamental importance for a wider life science community. The Cell Atlas, showing the subcellular localization of proteins in single cells.The Brain Atlas, exploring the distribution of proteins in various regions of the mammalian brain.The Blood Atlas, describing proteins detected in the blood cell types and proteins secreted by human tissues.The Pathology Atlas, showing the impact of protein levels for the survival of patients with cancer.The Single Cell Type Atlas, showing expression of protein-coding genes in single human cell types.The Tissue Atlas, showing the distribution of the proteins across all major tissues and organs in the human body.The Human Protein Atlas consists of six separate parts, each focusing on a particular aspect of the genome-wide analysis of the human proteins: All the data in the knowledge resource is open access to allow scientists both in academia and industry to freely access the data for exploration of the human proteome. The Human Protein Atlas is a Swedish-based program initiated in 2003 with the aim to map all the human proteins in cells, tissues and organs using an integration of various omics technologies, including antibody-based imaging, mass spectrometry-based proteomics, transcriptomics and systems biology.
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